There is proof for the induction of CYP2A6 in vivo by phenobarbital together with other anticonvulsant drugs. Two-working day cure with phenobarbital (a hundred mg on a daily basis p.o.) previous to a liver biopsy resulted in induction of metabolism of nicotine to cotinine in hepatocytes (Kyerematen et al. Potentials https://maindistro.com/