When an opiate binds as an agonist to the GPCR, there will be a signaling cascade leading to the inhibition of adenylate cyclase and calcium ion channels with the stimulation of potassium ion channels. The net effect of these improvements is often a reduced intracellular cAMP and hyperpolarization with the https://opioidsandalcohol95949.creacionblog.com/28600954/fascination-about-effects-of-opioids-on-the-brain