Epidural clonidine utilized as an adjunct to local anesthetics has a few different mechanisms of action. First, the stimulation of alpha-two-receptors while in the dorsal horn reduces discomfort transmission. Secondly, clonidine can result in community vasoconstriction that limits vascular elimination of area epidural anesthetics. Jun 10, 2024 · If https://www.proleviate.com/post/the-new-pain-killer-conolidine